We often see drinking and driving as recent problem (last 30 years or so) however the deadly combination of alcohol and motor vehicles has been know for over a century. When cars became common place, it didn't take a genius to realize that driving while intoxicated resulted in serious consequences. One of the earliest observations came from Puck magazine in 1907 depicting the Demon Rum driving a car at high speed.
An illustration from Puck magazine (1907) depicting the driver, Demon Rum. and four drunk passengers speeding carelessly. The caption states "One phase of it".
The sketch was published in the 1930s and depicts a death figure in the back seat of a car pointing towards a liquor bottle in the hand of the drunk driver.
A poster created in 1937/38 making the connection that alcohol and auto fuel (obviously symbolizing the car) can lead to death.